Production of Lipid-core/multilamellar-shell Hybrid Liposomes Utilizing Non-equilibrium Microfluidic Droplets
نویسندگان
چکیده
A microfluidic process has been newly proposed to synthesize highly unique micrometer-size hybrid liposomes having multi-lamellae structure. The process includes (1) formation of monodisperse droplets of a polar solvent containing phospholipids at a microchannel confluence, (2) dissolution of the solvent into the continuous water phase, and (3) simultaneous reconstitution of large multilayer membranes and formation of a lipid core. We successfully prepared monodisperse hybrid liposomes composed of a lipid core and a multilamellar shell, and demonstrated the applicability as carriers for both hydrophilic and hydrophobic compounds.
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